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Hippocampally-synthesized Estrogens Rapidly Facilitate Recognition Learning in Ovariectomized Mice

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dc.contributor.advisor Choleris, Theresa K Martin, Theresa K 2018-08-31T13:17:40Z 2018-08-31T13:17:40Z 2018-08 2018-08-23 2018-08-31
dc.description.abstract Estrogens are known to play a role in modulating cognition, including processes involved in recognition learning and memory. The hippocampus is known to synthesize its own estrogens, and the inhibition of this synthesis results in impaired recognition long-term memory. However, the role of locally-synthesized hippocampal estrogens in the encoding/early consolidation of recognition short-term memory (STM) remained unknown. 2-month-old, ovariectomized mice were hippocampally-infused with 2%-DMSO-vehicle, 0.01, 0.05 or 0.1µg/µL of letrozole before the habituation phase of an object, social or spatial recognition task. The results showed impairment in OR and SR STM in groups treated with 0.01 and 0.05µg/µL, but not 0.1µg/µL, and spatial STM only impaired with 0.1µg/µL dose of letrozole. These results suggest that locally-synthesized estrogen may contribute to STM formation and raises the possibility that stimulation of local estrogen biosynthesis in the brain could contribute to improved hormone replacement therapies for menopausal women. en_US
dc.description.sponsorship Natural Sciences and Engineering Research Council of Canada (NSERC) en_US
dc.language.iso en en_US
dc.subject Learning en_US
dc.subject Aromatase en_US
dc.subject Letrozole en_US
dc.subject Behavorial neuroendocrinology en_US
dc.subject Brain synthesized en_US
dc.subject Hormones en_US
dc.title Hippocampally-synthesized Estrogens Rapidly Facilitate Recognition Learning in Ovariectomized Mice en_US
dc.type Thesis en_US Neuroscience en_US Master of Science en_US Department of Psychology en_US
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