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Hippocampally-synthesized Estrogens Rapidly Facilitate Recognition Learning in Ovariectomized Mice

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Title: Hippocampally-synthesized Estrogens Rapidly Facilitate Recognition Learning in Ovariectomized Mice
Author: Martin, Theresa K
Department: Department of Psychology
Program: Neuroscience
Advisor: Choleris, Theresa K
Abstract: Estrogens are known to play a role in modulating cognition, including processes involved in recognition learning and memory. The hippocampus is known to synthesize its own estrogens, and the inhibition of this synthesis results in impaired recognition long-term memory. However, the role of locally-synthesized hippocampal estrogens in the encoding/early consolidation of recognition short-term memory (STM) remained unknown. 2-month-old, ovariectomized mice were hippocampally-infused with 2%-DMSO-vehicle, 0.01, 0.05 or 0.1µg/µL of letrozole before the habituation phase of an object, social or spatial recognition task. The results showed impairment in OR and SR STM in groups treated with 0.01 and 0.05µg/µL, but not 0.1µg/µL, and spatial STM only impaired with 0.1µg/µL dose of letrozole. These results suggest that locally-synthesized estrogen may contribute to STM formation and raises the possibility that stimulation of local estrogen biosynthesis in the brain could contribute to improved hormone replacement therapies for menopausal women.
URI: http://hdl.handle.net/10214/14140
Date: 2018-08


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