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Optimization of Imaging and Bronchoalveolar Lavage Techniques to Improve Diagnostic Yield of Feline Lower Respiratory Tract Samples

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dc.contributor.advisor Defarges, Alice
dc.contributor.author Hooi, Kimberly
dc.date.accessioned 2018-08-29T20:03:39Z
dc.date.available 2018-08-29T20:03:39Z
dc.date.copyright 2018-08
dc.date.created 2018-08-23
dc.date.issued 2018-08-29
dc.identifier.uri http://hdl.handle.net/10214/14126
dc.description.abstract The process of investigation of feline lower respiratory tract disease can present multiple difficulties to the veterinary practitioner. Radiography is considered the first line imaging diagnostic test; however, in a proportion of cats no changes are identified. To characterize the etiology of lower respiratory tract clinical signs, sampling of the lower respiratory tract is required. Bronchoalveolar lavage (BAL) is a minimally invasive technique that is utilized to collect samples from the distal airways and alveoli. Simply, this technique involves instillation of sterile saline and re-aspiration to collect bronchoalveolar lavage fluid. In cats, two main techniques have been described but have not been compared. The purpose of this research project was to compare the two techniques for BAL in cats – bronchoscopic-BAL (B-BAL) and non-bronchoscopic-BAL (NB-BAL) and their effect on sample quality in healthy cats without respiratory tract disease and to describe a new technique for collecting BAL fluid (BALF) in cats – fluoroscopic guided BAL (F-BAL). B-BAL retrieved a higher proportion of BALF than NB-BAL but there was no difference in the sample quality in regard to cellularity and cell preservation. Using fluoroscopy, it was determined that sampling of specific lung lobes was achievable and the BALF samples retrieved were of excellent cytologic quality, cellularity and cell preservation. Either B-BAL or NB-BAL can be utilized to collect BALF in cats with signs of lower respiratory tract disease, however in order to improve diagnostic yield of bronchoalveolar lavage, a technique that allows sampling of specific lung lobes should be considered. Therefore, where a bronchoscope is not available or feasible, F-BAL is a suitable alternative to B-BAL. en_US
dc.description.sponsorship OVC Pet Trust, University of Guelph Research Assistantship Program en_US
dc.language.iso en en_US
dc.rights Attribution 2.5 Canada *
dc.rights.uri http://creativecommons.org/licenses/by/2.5/ca/ *
dc.subject feline en_US
dc.subject endoscopy en_US
dc.subject respiratory tract en_US
dc.subject internal medicine en_US
dc.subject veterinary medicine en_US
dc.subject bronchoscopy en_US
dc.subject diagnostic imaging en_US
dc.subject fluoroscopy en_US
dc.subject hemosiderin en_US
dc.title Optimization of Imaging and Bronchoalveolar Lavage Techniques to Improve Diagnostic Yield of Feline Lower Respiratory Tract Samples en_US
dc.type Thesis en_US
dc.degree.programme Clinical Studies en_US
dc.degree.name Doctor of Veterinary Science en_US
dc.degree.department Department of Clinical Studies en_US
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Attribution 2.5 Canada Except where otherwise noted, this item's license is described as Attribution 2.5 Canada