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Anti-inflammatory Activity of Isomaltodextrin in a C57BL/6NCrl Mouse Model with Lipopolysaccharide-induced Low-grade Chronic Inflammation

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dc.contributor.advisor Mine, Yoshinori
dc.contributor.author Hann, Melissa
dc.date.accessioned 2018-08-29T19:16:29Z
dc.date.available 2018-08-29T19:16:29Z
dc.date.copyright 2018-08
dc.date.created 2018-08-24
dc.date.issued 2018-08-29
dc.identifier.uri http://hdl.handle.net/10214/14124
dc.description.abstract The purpose of this study was to identify the anti-inflammatory activity and mechanism of isomaltodextrin in a C57BL/6NCrl mouse model with lipopolysaccharide-induced systemic low-grade chronic inflammation and the effect on inflammation-induced metabolic disorders. Lipopolysaccharide induces inflammation by stimulating the expression of proinflammatory mediators. Low-grade chronic inflammation is associated with insulin resistance and other metabolic disorders. Treatment with isomaltodextrin led to reduced plasma concentrations of proinflammatory mediators TNF-α and MCP-1, and increased concentrations of adiponectin, an anti-inflammatory adipokine. Isomaltodextrin administration reduced plasma concentrations of endotoxin, decreased macrophage infiltration into adipocytes, and increased expression of mucin 2, mucin 4, and the tight junction protein claudin 4. These results suggest that isomaltodextrin administration exerted an anti-inflammatory effect on mice with lipopolysaccharide-induced inflammation, potentially by decreasing circulating endotoxin, suppressing proinflammatory mediators and macrophage infiltration, or by improving mucus or tight junction integrity. Isomaltodextrin had no impact on insulin resistance or obesity with a normal diet model. en_US
dc.description.sponsorship Ontario Graduate Scholarship en_US
dc.language.iso en en_US
dc.rights Attribution-NonCommercial-NoDerivs 2.5 Canada *
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/2.5/ca/ *
dc.subject isomaltodextrin en_US
dc.subject low-grade inflammation en_US
dc.subject chronic inflammation en_US
dc.subject prebiotic en_US
dc.title Anti-inflammatory Activity of Isomaltodextrin in a C57BL/6NCrl Mouse Model with Lipopolysaccharide-induced Low-grade Chronic Inflammation en_US
dc.type Thesis en_US
dc.degree.programme Food Science en_US
dc.degree.name Master of Science en_US
dc.degree.department Department of Food Science en_US
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Attribution-NonCommercial-NoDerivs 2.5 Canada Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 2.5 Canada