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Anti-inflammatory Activity of Isomaltodextrin in a C57BL/6NCrl Mouse Model with Lipopolysaccharide-induced Low-grade Chronic Inflammation

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Title: Anti-inflammatory Activity of Isomaltodextrin in a C57BL/6NCrl Mouse Model with Lipopolysaccharide-induced Low-grade Chronic Inflammation
Author: Hann, Melissa
Department: Department of Food Science
Program: Food Science
Advisor: Mine, Yoshinori
Abstract: The purpose of this study was to identify the anti-inflammatory activity and mechanism of isomaltodextrin in a C57BL/6NCrl mouse model with lipopolysaccharide-induced systemic low-grade chronic inflammation and the effect on inflammation-induced metabolic disorders. Lipopolysaccharide induces inflammation by stimulating the expression of proinflammatory mediators. Low-grade chronic inflammation is associated with insulin resistance and other metabolic disorders. Treatment with isomaltodextrin led to reduced plasma concentrations of proinflammatory mediators TNF-α and MCP-1, and increased concentrations of adiponectin, an anti-inflammatory adipokine. Isomaltodextrin administration reduced plasma concentrations of endotoxin, decreased macrophage infiltration into adipocytes, and increased expression of mucin 2, mucin 4, and the tight junction protein claudin 4. These results suggest that isomaltodextrin administration exerted an anti-inflammatory effect on mice with lipopolysaccharide-induced inflammation, potentially by decreasing circulating endotoxin, suppressing proinflammatory mediators and macrophage infiltration, or by improving mucus or tight junction integrity. Isomaltodextrin had no impact on insulin resistance or obesity with a normal diet model.
URI: http://hdl.handle.net/10214/14124
Date: 2018-08
Rights: Attribution-NonCommercial-NoDerivs 2.5 Canada
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Attribution-NonCommercial-NoDerivs 2.5 Canada Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 2.5 Canada