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Bayesian Clustering Approaches for Discrete Data

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dc.contributor.advisor Rothstein, Steven J. Silva, H. Anjali 2018-05-09T17:49:45Z 2020-06-19T05:00:51Z 2018-03 2018-03-15 2017-11-30
dc.description.abstract Unsupervised classification or clustering uses no a priori knowledge of the labels of the observations in the process of categorizing data. The research contained in this thesis focuses on the machine learning of discrete-valued gene expression datasets using clustering, with the aim of identifying gene co-expression networks. Specifically, a number of topics surrounding the use of mixture models and Markov chain Monte Carlo (MCMC) methods in clustering of discrete data from high-throughput transcriptome sequencing technologies is presented. After outlining current challenges and gaps in research with respect to clustering approaches, three mixture model-based clustering methods are presented: mixtures of multivariate Poisson-log normal distributions, mixtures of multivariate Poisson-log normal factor analyzers and mixtures of matrix-variate Poisson-log normal distributions. Significance, innovation, limitations and a number of future directions stemming from this research are discussed. en_US
dc.description.sponsorship Queen Elizabeth II Graduate Scholarship in Science & Technology; Ontario Graduate Fellowship; Arthur Richmond Memorial Scholarship; Canadian Statistical Sciences Institute Travel Scholarship; Statistical Society of Canada Travel Scholarship; Women in Machine Learning Travel Scholarships. en_US
dc.language.iso en en_US
dc.publisher en_US
dc.subject Clustering en_US
dc.subject RNA sequencing en_US
dc.subject Discrete data en_US
dc.subject Multivariate Poisson-Log Normal distribution en_US
dc.subject Markov chain Monte Carlo en_US
dc.subject Factor analyzers en_US
dc.subject Matrix variate distribution en_US
dc.subject Co-expression network en_US
dc.title Bayesian Clustering Approaches for Discrete Data en_US
dc.type Article en_US Bioinformatics en_US Doctor of Philosophy en_US Department of Mathematics and Statistics en_US
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dcterms.relation Silva A., Rothstein, S. J. McNicholas, P. D. and Subedi, S. (2017) A Multivariate Poisson-Log Normal Mixture Model for Clustering Transcriptome Sequencing Data. arXiv preprint arXiv:1711.11190.

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