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The Impact of Different Obesogenic Diets on the Severity of the Obese Phenotype and Colon Health in Male C57Bl/6 Mice

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dc.contributor.advisor Robinson, Lindsay
dc.contributor.advisor Power, Krista
dc.contributor.author Roberton, Kyle
dc.date.accessioned 2018-05-08T14:31:00Z
dc.date.available 2018-05-08T14:31:00Z
dc.date.copyright 2018-05
dc.date.created 2018-04-30
dc.date.issued 2018-05-08
dc.identifier.uri http://hdl.handle.net/10214/13008
dc.description.abstract High fat diets (HFDs) are commonly used to induce obesity in rodents, however the nutritional composition of these diets often vary dramatically and may result in variable effects on the obese phenotype. This thesis investigates how two commonly used HFDs (45%HFD (45% kcal from fat) and 60%HFD (60% kcal from fat)) differently affect aspects of the obese phenotype (adipose tissue dysfunction, metabolic dysregulation) and colon health (crypt histomorphology) when fed to 3- week-old male C57Bl/6 mice for 12 weeks compared to lean mice consuming low fat diet (17%LFD; 17% kcal from fat). Mice consuming 60%HFD had increased adiposity, gonadal adipose tissue macrophage infiltration, biomarkers of metabolic dysfunction (serum insulin, leptin), endotoxemia, colon crypt height, and goblet cell density compared to mice consuming 45%HFD and 17%LFD. Overall, findings suggest that the severity of the obese phenotype, and colon health in mice were dependant on the nutritional composition of their respective HFDs. en_US
dc.language.iso en en_US
dc.subject High Fat Diet (HFD) en_US
dc.subject Obesity en_US
dc.subject Endotoxemia en_US
dc.subject Gut en_US
dc.subject Colon en_US
dc.subject Goblet Cell en_US
dc.subject Mucous en_US
dc.subject Adipose Tissue en_US
dc.subject C57Bl/6 Mouse Model en_US
dc.subject 45%HFD en_US
dc.subject 60%HFD en_US
dc.title The Impact of Different Obesogenic Diets on the Severity of the Obese Phenotype and Colon Health in Male C57Bl/6 Mice en_US
dc.type Thesis en_US
dc.degree.programme Human Health and Nutritional Sciences en_US
dc.degree.name Master of Science en_US
dc.degree.department Department of Human Health and Nutritional Sciences en_US
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