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The Impact of Different Obesogenic Diets on the Severity of the Obese Phenotype and Colon Health in Male C57Bl/6 Mice

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Title: The Impact of Different Obesogenic Diets on the Severity of the Obese Phenotype and Colon Health in Male C57Bl/6 Mice
Author: Roberton, Kyle
Department: Department of Human Health and Nutritional Sciences
Program: Human Health and Nutritional Sciences
Advisor: Robinson, LindsayPower, Krista
Abstract: High fat diets (HFDs) are commonly used to induce obesity in rodents, however the nutritional composition of these diets often vary dramatically and may result in variable effects on the obese phenotype. This thesis investigates how two commonly used HFDs (45%HFD (45% kcal from fat) and 60%HFD (60% kcal from fat)) differently affect aspects of the obese phenotype (adipose tissue dysfunction, metabolic dysregulation) and colon health (crypt histomorphology) when fed to 3- week-old male C57Bl/6 mice for 12 weeks compared to lean mice consuming low fat diet (17%LFD; 17% kcal from fat). Mice consuming 60%HFD had increased adiposity, gonadal adipose tissue macrophage infiltration, biomarkers of metabolic dysfunction (serum insulin, leptin), endotoxemia, colon crypt height, and goblet cell density compared to mice consuming 45%HFD and 17%LFD. Overall, findings suggest that the severity of the obese phenotype, and colon health in mice were dependant on the nutritional composition of their respective HFDs.
URI: http://hdl.handle.net/10214/13008
Date: 2018-05
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