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Behaviour and Neural Indices of the Abuse Liability associated with Intraoral Self-administration of High Fructose Corn Syrup

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dc.contributor.advisor Parker, Linda Levy, AnneMarie 2018-04-30T15:20:00Z 2018-04-30T15:20:00Z 2018-04 2018-04-05 2018-04-30
dc.description.abstract Food addiction (FA) is characterized by addictive behaviours including compulsively eating and neurobiological alterations that emerge in response to consuming food. Evidence strongly suggests sucrose is addictive; however, this sweetener has been almost entirely replaced by high fructose corn syrup (HFCS) in food/drink. Interestingly, HFCS impairs metabolic function and its introduction into the food supply is linked to the emergence of a concurrent epidemic of obesity; yet, little is known about its addictive properties. Therefore, we investigated its abuse liability and characterized these effects relative to sucrose. Using a novel procedure for sugar self-administration (SA), intraoral SA (IOSA) of HFCS was concentration dependent and supported by caloric content. Repeated IOSA led to escalation of intake, bingeing, and enhanced motivation to lever-press, indicating HFCS is reinforcing and possesses abuse liability. Moreover, compared to sucrose, HFCS alters expression of dopamine-2 (D2R) and mu-opioid (MOR) receptor mRNA in a manner putatively associated with exposure to drugs of abuse and the development of addiction. This occurred despite lower levels of HFCS SA, suggesting it may have more potent reinforcing effects and greater abuse liability. Likewise, SA of pellets mimicking HFCS engendered less hypothalamic activation than sucrose; in line with evidence that high fructose sugars may contribute to poor appetite regulation and possibly excessive intake. Bupropion (BUP) and naltrexone (NTX) were investigated with respect to their ability to reduce HFCS SA when administered alone, because they diminish the reinforcing properties of abused drugs, and in combination (BUP+NTX), to mimic the pharmacological actions of Contrave®, used to enhance weight-loss. BUP+NTX and NTX reduced IOSA of HFCS and upregulated expression of anorexigenic pro-opiomelanocortin mRNA in the hypothalamus. Moreover, compared to drugs of abuse or IOSA of HFCS alone, the addition of BUP+NTX led to opposing effects on DR2 and MOR mRNA expression, suggesting novel applications for Contrave® in treating FA or substance related abuse disorders. Together, these studies provide novel evidence that HFCS is addictive and support adopting policies that may limit its availability to reduce the potential harm associated with HFCS consumption as well as curb rising rates of obesity in vulnerable individuals. en_US
dc.language.iso en en_US
dc.rights Attribution-NoDerivs 2.5 Canada *
dc.rights.uri *
dc.subject High Fructose Corn Syrup en_US
dc.subject Sucrose en_US
dc.subject Contrave en_US
dc.subject Bupropion en_US
dc.subject Naltrexone en_US
dc.subject Intraoral en_US
dc.subject Operant Self-administration en_US
dc.subject Bingeing en_US
dc.subject Escalation en_US
dc.subject High Fructose Corn Syrup en_US
dc.subject Saccharin en_US
dc.subject Taste Reactivity en_US
dc.subject Progressive Ratio en_US
dc.subject Food Addiction en_US
dc.subject Obesity en_US
dc.title Behaviour and Neural Indices of the Abuse Liability associated with Intraoral Self-administration of High Fructose Corn Syrup en_US
dc.type Thesis en_US Psychology en_US Doctor of Philosophy en_US Department of Psychology en_US
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Attribution-NoDerivs 2.5 Canada Except where otherwise noted, this item's license is described as Attribution-NoDerivs 2.5 Canada