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The role of Glycerol in supporting Energy Production in the Hagfish Heart during Anoxia Exposure

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dc.contributor.advisor Gillis, Todd Gatrell, Lauren 2018-01-25T16:07:50Z 2018-12-12T06:00:16Z 2017-12 2017-12-12 2018-01-25
dc.description.abstract Pacific and Atlantic hagfish are able to survive chronic (> 20 h) anoxia exposure and previous work demonstrates that hearts remain functional during this time. Isolated heart preparations in E. stoutii have shown glycogen stores are utilized during anoxia exposure but that these are not sufficient to generate the measured ATP production rate. One fuel source that could supplement tissue glycogen is glycerol, funneled into anaerobic glycolysis. This thesis aims to identify the possible role of cardiac lipid and glycerol stores in anoxic energy production in the hagfish. When the hearts were exposed to anoxia, there was a decreased developed pressure but not in the rate of pressure development or heart rate. Interestingly, the addition of glycerol caused an increase in cardiac function and in the activity of triglyceride lipase and G3PDH. en_US
dc.language.iso en en_US
dc.subject Atlantic hagfish en_US
dc.subject Myxine glutinosa en_US
dc.subject Pacific hagfish en_US
dc.subject Eptatretus stoutii en_US
dc.subject Heart en_US
dc.subject Anoxia en_US
dc.subject Cardiovascular en_US
dc.subject Glucose en_US
dc.subject Glycerol en_US
dc.subject Triglyceride lipase en_US
dc.subject Glycerol kinase en_US
dc.subject glycerol-3 phosphate dehydrogenase en_US
dc.title The role of Glycerol in supporting Energy Production in the Hagfish Heart during Anoxia Exposure en_US
dc.type Thesis en_US Integrative Biology en_US Master of Science en_US Department of Integrative Biology en_US

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