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The role of Glycerol in supporting Energy Production in the Hagfish Heart during Anoxia Exposure

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Title: The role of Glycerol in supporting Energy Production in the Hagfish Heart during Anoxia Exposure
Author: Gatrell, Lauren
Department: Department of Integrative Biology
Program: Integrative Biology
Advisor: Gillis, Todd
Abstract: Pacific and Atlantic hagfish are able to survive chronic (> 20 h) anoxia exposure and previous work demonstrates that hearts remain functional during this time. Isolated heart preparations in E. stoutii have shown glycogen stores are utilized during anoxia exposure but that these are not sufficient to generate the measured ATP production rate. One fuel source that could supplement tissue glycogen is glycerol, funneled into anaerobic glycolysis. This thesis aims to identify the possible role of cardiac lipid and glycerol stores in anoxic energy production in the hagfish. When the hearts were exposed to anoxia, there was a decreased developed pressure but not in the rate of pressure development or heart rate. Interestingly, the addition of glycerol caused an increase in cardiac function and in the activity of triglyceride lipase and G3PDH.
URI: http://hdl.handle.net/10214/12322
Date: 2018-01-25


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