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Dietary fat consumption and exercise as strategies to mitigate tumorigenesis in breast cancer

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dc.contributor.advisor Robinson, Lindsay E
dc.contributor.advisor Ma, David WL
dc.contributor.author Hucik, Barbora
dc.date.accessioned 2017-09-13T17:14:59Z
dc.date.available 2017-09-13T17:14:59Z
dc.date.copyright 2017-09
dc.date.created 2017-09-06
dc.date.issued 2017-09-13
dc.identifier.uri http://hdl.handle.net/10214/11582
dc.description.abstract Lifestyle habits such as regular exercise or the consumption of a healthy balanced diet may prevent up to 30-50% of breast cancer (BC) cases. Dietary fats are of specific interest, as research provides strong evidence regarding the association of different dietary fats and BC. Exercise also exerts protective effects in BC, yet the combination of various dietary fats and exercise has not been well-studied. Dietary fats exert anti-tumorigenic effects in BC via the incorporation of fatty acids into tumor tissue plasma membrane. This study shows that dietary fat and exercise independently modulate mammary tumor outcomes. Tumor volume and multiplicity was decreased in mice fed n-3 PUFA. Exercise inhibited tumor onset and development in n-6 PUFA-fed mice. Diet and exercise interventions should be investigated further as a means to improve mammary tumor outcomes in BC. en_US
dc.description.sponsorship Cancer Research Society en_US
dc.language.iso en en_US
dc.subject breast cancer en_US
dc.subject exercise en_US
dc.subject dietary fat en_US
dc.title Dietary fat consumption and exercise as strategies to mitigate tumorigenesis in breast cancer en_US
dc.type Thesis en_US
dc.degree.programme Human Health and Nutritional Sciences en_US
dc.degree.name Master of Science en_US
dc.degree.department Department of Human Health and Nutritional Sciences en_US
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