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Neural Stem/Progenitor Cells and Postnatal Neurogenesis in the Leopard Gecko Brain

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dc.contributor.advisor Vickaryous, Matthew McDonald, Rebecca 2017-09-06T19:03:21Z 2017-09-06T19:03:21Z 2017 2017-09-05 2017-09-06
dc.description.abstract Endogenous neural stem/progenitor cells (NSPCs) residing within neurogenic niches have been identified across vertebrate species. Here we explore neurogenesis in an emerging amniote model of central nervous system regeneration, the leopard gecko. We have identified a population of NSPCs in the ventricular zone along the entire neuraxis of the brain, and determined these NSPCs to be radial glia on the basis of their morphology and protein expression profile. Moreover, we found mitotically active populations both within, and independent of, the ventricular zone across the rostrocaudal extent of the brain. Using bromodeoxyuridine pulse-chase experiments, we found proliferation to directly contribute to neurogenesis in the medial cortex, generating new neurons which persist long-term. Further, we established that neurogenesis is resilient to a distal central nervous system injury, as it is unaltered by spinal cord rupture (as a result of tail loss). en_US
dc.description.sponsorship NSERC Discovery Grant 400358 en_US
dc.language.iso en en_US
dc.rights Attribution-NonCommercial-NoDerivs 2.5 Canada *
dc.rights.uri *
dc.subject neural stem cells en_US
dc.subject neurogenesis en_US
dc.subject lizard en_US
dc.subject gecko en_US
dc.subject regeneration en_US
dc.subject radial glia en_US
dc.title Neural Stem/Progenitor Cells and Postnatal Neurogenesis in the Leopard Gecko Brain en_US
dc.type Thesis en_US Biomedical Sciences en_US Master of Science en_US Department of Biomedical Sciences en_US
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Attribution-NonCommercial-NoDerivs 2.5 Canada Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 2.5 Canada