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Neural Stem/Progenitor Cells and Postnatal Neurogenesis in the Leopard Gecko Brain

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dc.contributor.advisor Vickaryous, Matthew
dc.contributor.author McDonald, Rebecca
dc.date.accessioned 2017-09-06T19:03:21Z
dc.date.available 2017-09-06T19:03:21Z
dc.date.copyright 2017
dc.date.created 2017-09-05
dc.date.issued 2017-09-06
dc.identifier.uri http://hdl.handle.net/10214/11547
dc.description.abstract Endogenous neural stem/progenitor cells (NSPCs) residing within neurogenic niches have been identified across vertebrate species. Here we explore neurogenesis in an emerging amniote model of central nervous system regeneration, the leopard gecko. We have identified a population of NSPCs in the ventricular zone along the entire neuraxis of the brain, and determined these NSPCs to be radial glia on the basis of their morphology and protein expression profile. Moreover, we found mitotically active populations both within, and independent of, the ventricular zone across the rostrocaudal extent of the brain. Using bromodeoxyuridine pulse-chase experiments, we found proliferation to directly contribute to neurogenesis in the medial cortex, generating new neurons which persist long-term. Further, we established that neurogenesis is resilient to a distal central nervous system injury, as it is unaltered by spinal cord rupture (as a result of tail loss). en_US
dc.description.sponsorship NSERC Discovery Grant 400358 en_US
dc.language.iso en en_US
dc.rights Attribution-NonCommercial-NoDerivs 2.5 Canada *
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/2.5/ca/ *
dc.subject neural stem cells en_US
dc.subject neurogenesis en_US
dc.subject lizard en_US
dc.subject gecko en_US
dc.subject regeneration en_US
dc.subject radial glia en_US
dc.title Neural Stem/Progenitor Cells and Postnatal Neurogenesis in the Leopard Gecko Brain en_US
dc.type Thesis en_US
dc.degree.programme Biomedical Sciences en_US
dc.degree.name Master of Science en_US
dc.degree.department Department of Biomedical Sciences en_US
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Attribution-NonCommercial-NoDerivs 2.5 Canada Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 2.5 Canada