Main content

Bioactivity of Bovine Colostrum and Milk Exosomes from High, Average, and Low Immune Responders on Human Intestinal Epithelial Cells

Show full item record

Title: Bioactivity of Bovine Colostrum and Milk Exosomes from High, Average, and Low Immune Responders on Human Intestinal Epithelial Cells
Author: Ross, Mikayla
Department: Department of Pathobiology
Program: Pathobiology
Advisor: Mallard, Bonnie
Abstract: Bovine colostrum and milk contain bioactive components that are nutritionally and immunologically important to calves and humans. While high (H) immune responder cows have improved colostrum and milk quality compared to average (A) and low (L) responders, bioactivity of colostrum and milk exosomes containing microRNAs on human intestinal epithelial cells was unknown. Therefore, the objectives of this research were to evaluate intestinal epithelial cell uptake, viability, and caspase 3 activity after co-culture with colostrum and milk exosomes from H, A, and L immune responders. Results indicated exosomes were taken up by epithelial cells, enhance cell viability, and activate the caspase 3 pathway. Further, this research provides novel insights into differences in bioactivity between colostrum and milk exosomes from H, A, and L immune responders, whereby cell viability was significantly greater after co-culture with H responder exosomes compared to L. Collectively, these findings suggest potential health benefits of cow’s milk.
URI: http://hdl.handle.net/10214/11538
Date: 2017-08
Terms of Use: All items in the Atrium are protected by copyright with all rights reserved unless otherwise indicated.


Files in this item

Files Size Format View Description
Ross_Mikayla_201709_Msc.pdf 29.18Mb PDF View/Open Thesis

This item appears in the following Collection(s)

Show full item record