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Investigating the role of hnRNP-M in asymmetric neural precursor cell divisions in the developing cerebral cortex

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dc.contributor.advisor Vessey, John Hillier, Dendra 2017-09-05T19:47:44Z 2018-08-23T05:00:24Z 2017-08 2017-08-23 2017-09-05
dc.description.abstract The mature cortex carries out many complex cognitive functions in the brain, such as reasoning and conscious thought. During brain development the process of neurogenesis expands the cortex through asymmetric divisions of neural precursor cells (NPCs). Asymmetric divisions are carried out, in part, through concise control of RNA expression. This research sought to expose a role for RNA-binding protein hnRNP-M in asymmetrically dividing NPCs. hnRNP-M was shown to be expressed in the nucleus during mouse cortical development by both NPCs and neurons. In vitro knockdown studies revealed changes in cellular populations, favouring the creation of NPCs and thereby suggesting a role in differentiation. This data, combined with knowledge from the literature, suggests hnRNP-M may regulate important alternative splicing events during asymmetric divisions of NPCs. The elucidation of the role of hnRNP-M provides insight into the molecular basis of brain development, and could have clinical applications for neurodevelopmental disorders. en_US
dc.description.sponsorship NSERC, Scottish Rite Charitable Foundation en_US
dc.language.iso en en_US
dc.rights Attribution 2.5 Canada *
dc.rights.uri *
dc.subject RNA binding protein en_US
dc.subject Neurodevelopment en_US
dc.subject cerebral cortex en_US
dc.subject hnRNP en_US
dc.title Investigating the role of hnRNP-M in asymmetric neural precursor cell divisions in the developing cerebral cortex en_US
dc.type Thesis en_US Molecular and Cellular Biology en_US Master of Science en_US Department of Molecular and Cellular Biology en_US
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Attribution 2.5 Canada Except where otherwise noted, this item's license is described as Attribution 2.5 Canada