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Investigating the role of hnRNP-M in asymmetric neural precursor cell divisions in the developing cerebral cortex

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Title: Investigating the role of hnRNP-M in asymmetric neural precursor cell divisions in the developing cerebral cortex
Author: Hillier, Dendra
Department: Department of Molecular and Cellular Biology
Program: Molecular and Cellular Biology
Advisor: Vessey, John
Abstract: The mature cortex carries out many complex cognitive functions in the brain, such as reasoning and conscious thought. During brain development the process of neurogenesis expands the cortex through asymmetric divisions of neural precursor cells (NPCs). Asymmetric divisions are carried out, in part, through concise control of RNA expression. This research sought to expose a role for RNA-binding protein hnRNP-M in asymmetrically dividing NPCs. hnRNP-M was shown to be expressed in the nucleus during mouse cortical development by both NPCs and neurons. In vitro knockdown studies revealed changes in cellular populations, favouring the creation of NPCs and thereby suggesting a role in differentiation. This data, combined with knowledge from the literature, suggests hnRNP-M may regulate important alternative splicing events during asymmetric divisions of NPCs. The elucidation of the role of hnRNP-M provides insight into the molecular basis of brain development, and could have clinical applications for neurodevelopmental disorders.
URI: http://hdl.handle.net/10214/11520
Date: 2017-08
Rights: Attribution 2.5 Canada


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Attribution 2.5 Canada Except where otherwise noted, this item's license is described as Attribution 2.5 Canada