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An Exploration of the Aversive Properties of 2-deoxy-D-glucose in the Context of Metabolic Dysfunction and Mood Disorders

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dc.contributor.advisor Leri, Francesco Horman, Thomas 2017-08-29T20:00:52Z 2017-08-29T20:00:52Z 2017-06 2017-08-17 2017-08-29
dc.description.abstract There is evidence that hypoglycemia alters mood and induces depressive-like behaviours. One method to precipitate a state of acute hypoglycemia is to administer the glucose antimetabolite 2-deoxy-D-glucose (2-DG). This thesis explored whether 2-DG could produce a conditioned place avoidance (CPA) in rats and examined whether pharmacological manipulation of monoamines could alter this effect. Pre-fed rats avoided a compartment paired with 2-DG (300 or 500 mg/kg). 2-DG also increased blood glucose and corticosterone (CORT), and suppressed locomotor activity. Interestingly food deprivation eliminated 2-DG-induced CPA, despite enhancing blood glucose and CORT levels. Clonidine (10 and 40 ug/kg) and bupropion (10 and 30 mg/kg) attenuated 2-DG-induced CPA and reduced increases in blood CORT caused by 2-DG, while bupropion reversed locomotor deficits. Overall, these results suggest that acute impairment of glucose metabolism can elicit a stress response which is aversive to rats, and which involves neurochemical mechanism of stress, arousal, and mood. en_US
dc.description.sponsorship This research was conducted with the support of the Ontario Brain Institute, an independent non-profit corporation, funded partially by the Ontario government. The opinions, results and conclusions are those of the authors and no endorsement by the Ontario Brain Institute is intended or should be inferred en_US
dc.language.iso en en_US
dc.subject Place avoidance en_US
dc.subject 2 deoxy-D-glucose en_US
dc.subject corticosterone en_US
dc.subject blood glucose en_US
dc.subject clonidine en_US
dc.subject bupropion en_US
dc.title An Exploration of the Aversive Properties of 2-deoxy-D-glucose in the Context of Metabolic Dysfunction and Mood Disorders en_US
dc.type Thesis en_US Psychology en_US Master of Science en_US Department of Psychology en_US
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