Main content

Experimentally Evoked Central Sensitization Does Not Modulate Dynamic Postural Responses to Medial-Lateral Perturbations in Healthy Young Adults

Show full item record

Title: Experimentally Evoked Central Sensitization Does Not Modulate Dynamic Postural Responses to Medial-Lateral Perturbations in Healthy Young Adults
Author: Malkin, Alexandra
Department: Department of Human Health and Nutritional Sciences
Program: Human Health and Nutritional Sciences
Advisor: Srbely, John
Abstract: This thesis is an investigation of the neuromuscular mechanisms associated with postural modulation after experimentally-induced central sensitization during dynamic movement. Central sensitization is an important mechanism in the development and maintenance of chronic pain and there’s evidence to suggest that it has the ability to modulate muscle activity and resulting balance. Our hypothesis states that capsaicin-induced central sensitization at the C4/C5 spinal segments leads to delayed leg muscle onset and time-to-peak amplitude following platform perturbations. Participants stood on a robotic motion platform and these outcome measures were quantified using surface electromyography during platform perturbations. The findings suggest that central sensitization does not change leg muscle onset and time-to-peak amplitude during medial-lateral perturbations compared to non-sensitized controls. Although some muscles showed significance in these outcome measures, overall, the findings suggest that capsaicin-induced central sensitization does not have a significant impact on leg muscle activity required to maintain balance during medial-lateral perturbations.
URI: http://hdl.handle.net/10214/10428
Date: 2017-05


Files in this item

Files Size Format View
Malkin_Alexandra_201705_Msc.pdf 36.42Mb PDF View/Open

This item appears in the following Collection(s)

Show full item record