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Investigation of factors associated with mortality and vaccination effectiveness during an outbreak of Streptococcus suis disease in a swine nursery

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Title: Investigation of factors associated with mortality and vaccination effectiveness during an outbreak of Streptococcus suis disease in a swine nursery
Author: Hopkins, Danielle
Department: Department of Population Medicine
Program: Population Medicine
Advisor: Friendship, Robert
Abstract: An investigation was conducted into the potential risk factors associated with mortality during an outbreak of Streptococcus suis disease in weanling pigs. Retrospective data were used to identify both sow- and pig-level factors that could result in increased risk of mortality. A Cox’s hazard regression model identified pigs originating within certain litters that appeared to be at increased risk. Risk for individual pigs increased if a littermate died or if the pig originated from a litter where the sow’s previous litter had low mortality. During the outbreak, a proportion of litters were vaccinated using an autogenous bacterin. Direct, indirect, total, and overall measures of vaccine effectiveness were evaluated using Cox’s hazard and binomial regression models. Measures of total (~27%) and overall (~21%) vaccine effectiveness had the largest estimated magnitude, with no evidence of direct effectiveness. Overall, there is potential for benefits of vaccination despite lack of evidence of direct effectiveness.
URI: http://hdl.handle.net/10214/10319
Date: 2017-03
Rights: Attribution 2.5 Canada
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Attribution 2.5 Canada Except where otherwise noted, this item's license is described as Attribution 2.5 Canada