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Effects of Prenatal Testosterone Exposure and Adult Hormone Manipulation on Social Learning, Social Interactions, and Anxiety-Like Behaviour in Male and Female CD1 Mice

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Title: Effects of Prenatal Testosterone Exposure and Adult Hormone Manipulation on Social Learning, Social Interactions, and Anxiety-Like Behaviour in Male and Female CD1 Mice
Author: Howes, Colin
Department: Department of Psychology
Program: Psychology
Advisor: Choleris, ElenaMacLusky, Neil
Abstract: We investigated interactions between organizational and activational effects of gonadal hormones on social behaviour and cognition. Dams were treated with testosterone propionate or sesame oil control. Litters underwent a battery of behavioural assays in adolescence and in adulthood, following sham surgery, gonadectomy, or gonadectomy with estradiol/testosterone replacement. Castration improved social learning in male mice treated prenatally with oil, but blocked learning in mice treated prenatally with testosterone. Social learning was blocked in ovariectomized female mice treated prenatally with testosterone, but was recovered via estradiol replacement. Male mice were less sociable than females, and prenatal testosterone exaggerated this difference. Prenatal testosterone shifted male mice from dominance aggression towards territorial aggression when interacting with a cage-mate, and reduced submissiveness in interactions with an intruder among females. Prenatal testosterone increased anxiety-like behaviour only in male mice. Our results have implications for understanding the role of hormones in mediating social and social cognitive behaviour.
URI: http://hdl.handle.net/10214/10138
Date: 2016-12
Rights: Attribution 2.5 Canada


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Attribution 2.5 Canada Except where otherwise noted, this item's license is described as Attribution 2.5 Canada