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Oral Bioaccessibility of Nickel in Various Particle Sizes of House Dust from Communities Close to Nickel Mining and Smelting Operations

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dc.contributor.advisor Hale, Beverley Dai, Nancy 2016-12-20T20:51:43Z 2017-12-31T06:00:14Z 2016-12 2016-11-01 2016-12-20
dc.description.abstract Particle size is known to influence leaching of Ni from soil and dust particles for total [Ni] and bioaccessibility. Little research has been done on Canadian dusts that contain Ni from mining and smelting sources, which may differ in speciation from that in the current literature. This work extends knowledge to a different set of samples. The relationship between particle size and oral nickel bioaccessibility was examined in pooled house dust previously studied in the Sudbury Soils Study. Dusts were separated into ranges of <10 µm, 10-41 µm, 41-70 µm, 70-105 µm, and 105-250 µm diameter fractions. Total [Ni] was determined following a modified reverse aqua regia acid digestion assay. Bioaccessibility was determined following the SBRC method. Both total and bioaccessible [Ni] increased inversely with particle size, though the relationship varied based on the dust group. Particle size and total [Ni] together explained much more of the variance in bioaccessible [Ni]. Bioaccessibility percentages were adjusted for their relative mass in each particle size range. Particles <10 µm and between 41 and 70 µm had high Ni bioaccessibility, and particles <10 µm and between 70 and 105 µm were highest after weight adjustment. Study results support that a more appropriate particle size for risk assessment use may be smaller than 250 µm. An upper limit of 105 µm is recommended. en_US
dc.description.sponsorship NSERC CRD, Vale, Glencore en_US
dc.language.iso en en_US
dc.subject nickel en_US
dc.subject particle size en_US
dc.subject bioaccessibility en_US
dc.subject dust en_US
dc.subject indoor pollutants en_US
dc.subject metal en_US
dc.subject Research Subject Categories en_US
dc.subject toxicity en_US
dc.subject SBRC en_US
dc.subject risk assessment en_US
dc.subject Sudbury Soils Study en_US
dc.title Oral Bioaccessibility of Nickel in Various Particle Sizes of House Dust from Communities Close to Nickel Mining and Smelting Operations en_US
dc.type Article en_US
dc.type Preprint en_US
dc.type Thesis en_US Toxicology en_US Master of Science en_US School of Environmental Sciences en_US
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