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Catheter Validation within a Simulated Pulsatile Flow System

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Title: Catheter Validation within a Simulated Pulsatile Flow System
Author: Fiedler, Erika Leah
Department: School of Engineering
Program: Engineering
Advisor: Runciman, John
Abstract: This thesis contains a study that used a simulated pulsatile flow system to perform catheter validation using distance interferometers. A synthetic artery composed of Ninjaflex, a formulated thermoplastic polyurethane material, was set up within an ex vivo system. The artery was used to mimic the basic structure and elastic nature of an equine pulmonary artery. The aim was to replicate in vivo arterial hemodynamic flow using a stepper motor controlled valve to validate catheter pulse wave velocity measurement. The synthetic artery was subjected to simulated pulsatile flow in a pre-existing ex vivo system designed for a study, part of a larger program, which developed a navigation technique for in vivo equine pulmonary arterial catheterization. During testing performed for this thesis a dual pressure catheter was inserted into the synthetic artery to measure pressure. Four distance interferometers were fixed external to the artery to measure its distension when pulses traveled through the artery. The instruments were place in pairs, a proximal and distal sensor on two separate axes, one on top and another located on the side of the artery. A Matlab code was used to obtain time delay values from the catheter pressure sensors and the two distance interferometer pairs. Pulse wave velocity values were calculated from the time delay values using the known sensor separation distances. The catheter proved to be able to measure pulse waveforms with a high degree of accuracy. Valve opening, dwell and closing times were changed to create varying pulse waveforms that the catheter was able to detect. The distance interferometers were not able to provide the same degree of accuracy when measuring waveforms, however they were able to show basic waveform patterns. Modifications are needed for device setup, including material choice and sensor separation distance in order for distance interferometers to be used to measure pulse wave velocity for catheter validation. This thesis aims to add to the knowledge base encompassing instrumentation for hemodynamic measurement in order to help work towards advancements for cures for exercise induced pulmonary hemorrhaging in equine athletes as well as human cardiovascular conditions.
Date: 2016-09
Rights: Attribution-NoDerivs 2.5 Canada
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Attribution-NoDerivs 2.5 Canada Except where otherwise noted, this item's license is described as Attribution-NoDerivs 2.5 Canada