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Intracerebroventricular (ICV) Administration of a CB1 Inverse Agonist as a Potential Model with which to Examine the Influence of the Endocannabinoid System in Anhedonia

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Title: Intracerebroventricular (ICV) Administration of a CB1 Inverse Agonist as a Potential Model with which to Examine the Influence of the Endocannabinoid System in Anhedonia
Author: Haynes, Danielle
Department: Department of Psychology
Program: Psychology
Advisor: Leri, FrancescoParker, Linda
Abstract: Recent evidence has implicated the CB1 receptor in anhedonia. CB1 inverse agonists in particular have been shown to elicit anhedonia in humans, and suppress intake and hedonic response to palatable food in laboratory animals, indicative of anhedonia. However, the majority of these findings in animals originate from studies employing systemic administration, which also results in nausea. Recent evidence indicates administration of CB1 inverse agonists directly to the lateral ventricles eliminates the nausea component. The present thesis examined whether chronic and/or acute intracerebroventricular (ICV) administration of CB1 inverse agonist AM251 can induce anhedonia. Hedonic capacity was assessed via ad libitum consumption of a high-fructose corn syrup (HFCS) solution and taste reactivity to HFCS. Chronic, but not acute, ICV AM251 resulted in a transient, selective decrease in HFCS consumption, suggesting that chronic central CB1 inverse agonism can induce an acute anhedonic state, and further implicating the central CB1 receptor in clinical anhedonia.
URI: http://hdl.handle.net/10214/10020
Date: 2016-09


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