The role of specific estrogen receptors in mediating rapid estrogenic improvements of social learning in female mice

dc.contributor.advisorCholeris, Elena
dc.contributor.authorErvin, Kelsy
dc.date.accessioned2014-01-14T20:55:12Z
dc.date.available2014-01-14T20:55:12Z
dc.date.copyright2013-12
dc.date.created2013-12-12
dc.date.issued2014-01-14
dc.degree.departmentDepartment of Psychologyen_US
dc.degree.grantorUniversity of Guelphen_US
dc.degree.nameMaster of Scienceen_US
dc.degree.programmePsychologyen_US
dc.description.abstractSocial learning is a process by which an animal gains information from another; however much of the research on estrogens effects on learning focuses on individual learning tasks. We therefore examined the effects of 17-estradiol (17beta-E2) and agonists for the estrogen receptors (ERs) ER-alpha, ER-beta, and the G protein-coupled ER 1 (GPER1) on the social transmission of food preferences (STFP) task, within a time scale allowing us to determine the rapid effects of estrogens. General ER activation with 17beta-E2 rapidly improved social learning on this task. Specific activation of the GPER1 also rapidly improved social learning, suggesting that 17beta-E2 acts through the GPER1 to rapidly improve learning on the STFP. Activation of ER-alpha and ER-beta activation, however, induced some impairing effects on learning. Rapid estrogenic modulation of social learning in the STFP therefore likely depends on the receptors activated, as each ER differently affected learning on this task.en_US
dc.identifier.urihttp://hdl.handle.net/10214/7818
dc.language.isoenen_US
dc.publisherUniversity of Guelphen_US
dc.rightsAttribution 2.5 Canada*
dc.rights.urihttp://creativecommons.org/licenses/by/2.5/ca/*
dc.subjectestradiolen_US
dc.subjectsocial transmission of food preferenceen_US
dc.subjectestrogen receptor alphaen_US
dc.subjectestrogen receptor betaen_US
dc.subjectG protein-coupled estrogen receptoren_US
dc.subjectGPERen_US
dc.subjectGPR30en_US
dc.titleThe role of specific estrogen receptors in mediating rapid estrogenic improvements of social learning in female miceen_US
dc.typeThesisen_US

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