Pro- and anti-angiogenic factors and receptors in the success and failure of porcine pregnancy

dc.contributor.advisorTayade, Chandra
dc.contributor.advisorLaMarre, Jonathan
dc.contributor.authorEdwards, Andrew Kenneth of Biomedical Sciencesen_US of Guelphen_US of Scienceen_US
dc.description.abstractCommercial swine breeds in North.America undergo two waves of spontaneous fetal loss; one during peri-attachment and another during mid-gestation. Attachment sites of arresting conceptuses are associated with decreased vasculature. Previous studies have found decreased VEGF family members at sites of fetal arrest. It was hypothesized that a balance between pro-angiogenic and anti-angiogenic factors is needed at the maternal-fetal interface for successful conceptus development. Selected members of the proangiogenic FGF and PDGF familier and anti-angiogenic factor TSP-1 and receptor CD36 were quantified and localized at the porcine maternal-fetal interface. Transcript levels of FGF and PDGF family members were elevated at sites of arrest, indicating a potential survival mechanism to compensate for decreased VEGF expression. Thrombospondin-1 and CD36 were transcribed at the maternal-fetal interface and their expression was localized to peri-vascular areas. These studies localize the genes of interest to the maternal-fetal interface and reveal dynamic expression patterns related to potential for fetal survival.en_US
dc.publisherUniversity of Guelphen_US
dc.rights.licenseAll items in the Atrium are protected by copyright with all rights reserved unless otherwise indicated.
dc.subjectNorth Americaen_US
dc.subjectspontaneous fetal lossen_US
dc.subjectdecreased vasculatureen_US
dc.subjectpro-angiogenic factorsen_US
dc.subjectanti-angiogenic factorsen_US
dc.subjectvascular endothelial growth factoren_US
dc.titlePro- and anti-angiogenic factors and receptors in the success and failure of porcine pregnancyen_US


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