Resveratrol and Metformin Combination Therapy in Prevention and Treatment of Insulin Resistance




Frendo-Cumbo, Scott

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University of Guelph


We sought to examine the combined (COM) effects of resveratrol (RSV), a polyphenol, and metformin (MET), a commonly prescribed anti-diabetic drug, in treatment and prevention of insulin-resistance. For examination of treatment effects, mice were fed a low (LFD) or high (HFD) fat diet to induce insulin-resistance. HFD mice were then separated into control HFD, MET, RSV, and COM. COM improved glucose and insulin tolerance compared to HFD. MET improved insulin tolerance, while RSV had no independent effects. COM increased insulin-stimulated phosphorylation of Akt in triceps and scAT. To examine prevention effects, mice were separated into LFD, HFD, MET, RSV and COM at the onset of dietary interventions. MET, RSV and COM therapy prevented HFD-induced glucose intolerance and exhibited significantly greater insulin tolerance compared to HFD. COM increased Akt phosphorylation in triceps and scAT compared to HFD. RSV, MET and COM increased eWAT Akt phosphorylation compared to HFD.



Resveratrol, Metformin, Combined Therapy, Insulin-Resistance