Effects of Early, Elevated Prenatal Testosterone on the HPA Axis and Hormone Responsiveness in Mice

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dc.contributor.advisorMacLusky, Neil James
dc.contributor.advisorCholeris, Elena
dc.contributor.authorWilson, Hayley Ann
dc.date.accessioned2019-05-15T20:35:00Z
dc.date.available2019-05-15T20:35:00Z
dc.date.copyright2019-05
dc.date.created2019-05-07
dc.date.issued2019-05-15
dc.degree.departmentDepartment of Biomedical Sciencesen_US
dc.degree.grantorUniversity of Guelphen_US
dc.degree.nameMaster of Scienceen_US
dc.degree.programmeBiomedical Sciencesen_US
dc.description.abstractAlterations in developmental testosterone exposure can affect social and anxiety behaviour in male offspring, however, the underlying mechanisms remain unknown. We hypothesized that prenatal testosterone exposure would impact physiological development in a similar way as prenatal glucocorticoid exposure, resulting in altered hypothalamic-pituitary-adrenal axis functioning and hormone profiles in offspring. We treated dams with testosterone propionate, the synthetic glucocorticoid dexamethasone, or sesame oil during mid-late pregnancy. Testosterone was measured in male offspring on the day of birth and in adulthood. Corticosterone was measured in offspring’s hair, and in plasma following restraint stress. Prenatal treatment did not affect offspring testosterone levels. While prenatal testosterone had no effect on corticosterone levels in hair, prenatal testosterone reduced corticosterone responsivity to restraint stress in males, but not females. No effects of prenatal dexamethasone on corticosterone responsivity was observed. This study may have potential implications for conditions in which testosterone or dexamethasone are elevated during pregnancy.en_US
dc.description.sponsorshipNatural Sciences and Engineering Research Council of Canada
dc.identifier.urihttp://hdl.handle.net/10214/16111
dc.language.isoenen_US
dc.publisherUniversity of Guelphen_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjecttestosteroneen_US
dc.subjectsex differencesen_US
dc.subjectHPA axisen_US
dc.subjectprenatal developmenten_US
dc.titleEffects of Early, Elevated Prenatal Testosterone on the HPA Axis and Hormone Responsiveness in Miceen_US
dc.typeThesisen_US
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