Immunity to and transport of sporozoites of Eimeria species in the domestic fowl, Gallus domesticus

dc.contributor.advisorFernando, M.A.
dc.contributor.advisorBarta, J.R.
dc.contributor.authorBeattie, Savannah Ellen
dc.date.accessioned2020-08-24T15:45:19Z
dc.date.available2020-08-24T15:45:19Z
dc.date.copyright1997
dc.degree.departmentDepartment of Pathobiologyen_US
dc.degree.grantorUniversity of Guelphen_US
dc.degree.nameMaster of Scienceen_US
dc.description.abstractEimeria maxima sporozoites penetrate epithelial cells, are transported through the lamina propria and continue development within the crypt epithelium. In immunized birds challenged with the homologous strain, sporozoites tend to accumulate in the lamina propria with few reaching the crypts by 72 hours post-challenge. The lack of cross-protection previously observed between the Guelph and Florida strains of E. maxima was partially manifested at the level of sporozoite transport. A higher percentage of sporozoites reached the crypt epithelium in immunized birds challenged with the heterologous strain than in immunized birds challenged with the homologous strain. Sporozoites of E. necatrix were observed within mononuclear cells that were CD 3$\sp+$ (15%), CD 8$\sp+$ (13-22%), $\delta\gamma$ TCR$\sp+$ (5%) and $\alpha\beta$ TCR$\sp+$ (5%) lymphocytes. Sporozoites were not observed within CD 4$\sp+$ or IgM$\sp+$ lymphocytes. A proportion ($>$50%) of sporozoites are transported within cells not stained by the panel of antibodies used in this study.en_US
dc.identifier.urihttps://hdl.handle.net/10214/19924
dc.language.isoen
dc.publisherUniversity of Guelphen_US
dc.rights.licenseAll items in the Atrium are protected by copyright with all rights reserved unless otherwise indicated.
dc.subjectDomestic fowlen_US
dc.subjectSporozoitesen_US
dc.subjectEimeria speciesen_US
dc.subjectImmunized birdsen_US
dc.subjectCrypt epitheliumen_US
dc.titleImmunity to and transport of sporozoites of Eimeria species in the domestic fowl, Gallus domesticusen_US
dc.typeThesisen_US

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