Changes in body composition, anaerobic muscle power, and pulmonary function with age in children with cystic fibrosis

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Authors

Schurer, Geertruida Wilhelmina

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University of Guelph

Abstract

To describe nutritional, anaerobic muscle power, and pulmonary function changes with age in children with cystic fibrosis (CF) aged 5-18y, retrospective data from 55 children (22M, 33F) were studied from 480 clinic visits from 1985-1996, and compared with 130 healthy children (COMP) (89M, 41F), as well as between CF children homozygous (HOM) or heterozygous (HET) for genotype ΔF508 (n = 42). Nutritional status outcomes included body mass, height, as well as body fat and fat free mass (FFM) estimated from skinfolds (SF) and bioimpedance analysis (BIA). The Wingate anaerobic test measured leg peak power (PP) and mean power (MP). Forced expiratory volume per 1 second (FEV\sb1) was measured by spirometry. Data were analyzed using multiple and single regression analysis with slopes compared (p < 0.05). Body composition from SF and BIA were highly correlated (R\sp2 = 0.391-0.981). Nutritional status was similar between CF and COMP children, but was poorer in HOM-F versus HET-F (p = 0.002). Anaerobic power was an indicator of FFM (p < 0.001). Yet muscle power, independent of FFM, was reduced with age in CF-F versus COMP-F (PP/FFM, p = 0.008; MP/FFM, p < 0.003), and in HOM-F versus HET-F (PP/FFM, p = 0.013; MP/FFM, p = 0.013). Change in anaerobic MP with age was reduced in CF-M versus COMP-M (p = 0.003), although higher for PP/BM (p < 0.001). While HOM-M versus HET-M had reduced pulmonary function (p = 0.003), PP but not MP, was significantly lower (p = 0.043, p = 0.058, respectively). Genotype ΔF508 plays a role in reduced nutritional status and anaerobic muscle power change with age in girls, seemingly independent of pulmonary function. Influences differed in boys, with reduced mean power changes in CF versus COMP and lung function in HOM versus HET groups.

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Keywords

body composition, anaerobic muscle power, pulmonary function, children, Cystic fibrosis

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