Functional genes and regulatory elements influencing immune response of sheep to gastrointestinal nematode infection

dc.contributor.advisorCanovas, Angela
dc.contributor.authorWilloughby, Olivia
dc.date.accessioned2023-05-16T20:33:05Z
dc.date.copyright2023-04
dc.date.created2023-04-26
dc.degree.departmentDepartment of Animal Biosciencesen_US
dc.degree.grantorUniversity of Guelphen
dc.degree.nameMaster of Scienceen_US
dc.degree.programmeAnimal Biosciencesen_US
dc.description.abstractInfection with gastrointestinal nematodes is challenging and costly for sheep producers and impacts the economic efficiency of farms and reduces the welfare of infected animals. There is evidence that resistance to gastrointestinal nematodes is a heritable trait in sheep, and genetic selection for this trait is a novel method for Canadian sheep producers to reduce levels of gastrointestinal nematode infection in their flocks. This thesis sought to identify functional regulatory elements including genes, mRNA isoforms, and long non-coding RNA that regulate the host immune response to gastrointestinal nematode infection in sheep using hepatic tissue collected from animals with various levels of gastrointestinal nematode infection and immune responsiveness. A list of candidate key regulatory genes, mRNA isoforms, and long non-coding RNAs were identified. These candidate regulatory elements may be used in future genomic selection programs to increase the resistance of grazing sheep to infection by gastrointestinal nematodes.en_US
dc.description.embargo2024-04-27
dc.description.sponsorshipFood from Thought
dc.description.sponsorshipHQP scholarship
dc.identifier.urihttps://hdl.handle.net/10214/27603
dc.language.isoenen_US
dc.publisherUniversity of Guelphen
dc.rights.licenseAll items in the Atrium are protected by copyright with all rights reserved unless otherwise indicated.
dc.subjectsheepen_US
dc.subjectgastrointestinal nematode infectionen_US
dc.subjectRNA-Sequencingen_US
dc.subjecttranscriptomicsen_US
dc.titleFunctional genes and regulatory elements influencing immune response of sheep to gastrointestinal nematode infectionen_US
dc.typeThesisen

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