Genetic variation in salt taste receptors impact salt intake, blood pressure and cardiovascular disease risk factors in the Guelph Family Health Study
The objective of this thesis was to investigate polymorphisms found in salt taste receptors on dietary sodium intake, blood pressure and cardiovascular disease (CVD) risk factors in children and parents of the Guelph Family Health Study (GFHS). The study was a cross-sectional analysis of 70 families (children, n=95 and parents, n=117). A primary finding showed that children, T allele carriers of the rs239345 (A>T) polymorphism consumed 34% more sodium than the AA genotype. Child and female adult carriers of the T allele of the rs8065080 (C>T) polymorphism consumed 21% and 41% lower amounts of sodium respectively. Findings show that genetic polymorphisms in genes SCNN1b and TRPV1 may influence sodium consumption and CVD risk in adults and children.