Ion-Pairing Mechanism for the Valinomycin-Mediated Transport of Potassium Ions Across Phospholipid Bilayers

dc.contributor.authorSu, Z.F.
dc.contributor.authorLeitch, J.J.
dc.contributor.authorSek, S.
dc.contributor.authorLipkowski, J.
dc.date.accessioned2022-01-28T16:48:08Z
dc.date.available2022-01-28T16:48:08Z
dc.date.createdJul-21
dc.degree.departmentElectrochemical Technology Centreen
dc.degree.departmentDepartment of Chemistryen
dc.description.abstractThe role of the anion on the ionophore properties of valinomycin was studied in a model floating bilayer lipid membrane (fBLM) using supporting electrolytes containing K+ with four different counter anion species (ClO4–, H2PO4–, Cl–, and F–). The electrochemical impedance spectra indicate that the membrane resistance of the bilayer decreases with the decrease of Gibbs free energy of anion solvation. The IR spectra demonstrate that valinomycin does not readily bind to K+ in the KH2PO4, KCl, and KF electrolyte solutions, but in the presence of KClO4, valinomycin readily binds to K+, forming a valinomycin–K+ complex. The results in the present paper reveal the role of the counter anion on the transport of cations by valinomycin across the lipid bilayer. The valinomycin–cation complex creates an ion pair with the anion, and this ion pair can enter the hydrophobic region of the bilayer transporting the cation across the membrane. Anions with low solvation energies facilitate the formation of the ion pair improving the ion conductivity of valinomycin-incorporated bilayers. This paper sheds new light on the transport mechanism of valinomycin ionophores and provides new information about the bioactivity of this molecule.en_US
dc.description.sponsorshipNatural Sciences and Engineering Research Council of Canada (NSERC)en_US
dc.identifier.urihttps://hdl.handle.net/10214/26751
dc.language.isoenen_US
dc.publisherACS Publicationen_US
dc.rights.licenseAll items in the Atrium are protected by copyright with all rights reserved unless otherwise indicated.
dc.subjectvalinomycinen_US
dc.subjection pairen_US
dc.subjectEISen_US
dc.subjectPM-IRRASen_US
dc.titleIon-Pairing Mechanism for the Valinomycin-Mediated Transport of Potassium Ions Across Phospholipid Bilayersen_US
dc.typeArticleen_US
dcterms.relationZhangFei Su,J. Jay Leitch, Slawomir Sek,and Jacek Lipkowski, Ion-Pairing Mechanism for the Valinomycin-Mediated Transport of Potassium Ions Across Phospholipid Bilayers.Langmuir 2021, 37, 31, 9613–9621. https://doi.org/10.1021/acs.langmuir.1c01500en_US

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