Synthesis and Investigation of Graphene-based Nanomaterials for Antimicrobial Applications

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Khaleel, Aiman

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University of Guelph


With the global rise in infectious disease, the demand for novel antimicrobial materials has risen to match. Nanomaterials in particular offer a novel solution as their unique properties allows them to have great activity relative to their quantity. This thesis focuses on the use of graphene-based nanocomposites as viable antimicrobial nanomaterials. Initially, a literature review is done to highlight the recent advances in the field and discuss avenues that can be taken. The first project focuses on silver-loaded graphene-based materials. Antibacterial activity of the silver materials against E. coli reached up to 93.4%, and up to 97% and 70% for S. enterica and S. aures, respectively. Using thiocoumarin silver sensor 1 (TcAg1) dye to investigate the mechanism of activity, it was concluded that the mechanism of activity of all the materials investigated in this thesis is the release of silver ions that would then attack the cellular structure of the bacteria. In the second project, bimetallic silver copper nanocomposites are formed on graphene oxide and the antibacterial activity was investigated for possible synergistic effects.



Graphene Oxide, Antimicrobial materials, Nanomaterials