The effects of exercise intensity of PGC-1alpha protein in humans



Robinson, Meghann J.

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University of Guelph


The protein nuclear co-activator peroxisome proliferators-activated receptor-gamma co-activator-1[alpha] (PGC-1[alpha]) is influenced by exercise intensity. Seven recreationally active, male subjects (22 ± 3.2y, VO2max 52.6 ± 1.8 mL·kg·min) exercised for 1h at 40, 60 and 80% VO2max followed by a 4 h recovery period. PGC-1[alpha] protein increased after exercise in the 60% VO2max trial, reaching significance by 4 h of recovery (P<0.05). Exercise at 80% VO2max resulted in significantly lower PGC-1[alpha] protein when compared to resting values and other exercise conditions (P<0.05). In contrast, PGC-1[beta] protein did not change with exercise. Glycogen levels decreased in response to exercise at 60% VO2max (P<0.05) with significantly greater depletion at 80% VO2max (P<0.05). The ratio of phosphorylated AMPK to total AMPK (pAMPK/AMPKT) increased significantly immediately after exercise at 80% VO2max (P<0.05) and remained during recovery. The changes in PGC-1[alpha] protein cannot be explained by the changes in glycogen or the activation of AMPK.



exercise intensity, PGC-1alpha protein, humans, PGC-1Beta protein, glycogen