Inclusion compounds of leucyl-alanine

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Yazdani, Abdolreza

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University of Guelph


The ability of L-leucyl-L-alanine dipeptide (Leu-Ala) to form inclusion compounds with ~20 guest molecules was studied using preparation, thermal analysis (TGA and DSC), X-ray diffraction (single crystal and powder), spectroscopy (FT-IR), and other methods. Inclusion compounds with unsubstituted pyridine, ten pyridine derivatives, quinoline, isoquinoline and guaiacol were prepared for the first time and their composition, thermal stability and dissociation mechanisms were studied. The crystal structures and bulk properties of inclusions with three methylpyridine isomers were investigated. The T/X phase diagrams of the systems Leu-Ala – DMSO and Leu-Ala – guaiacol were determined to reveal the conditions of formation, limits of existence and modes of decomposition of the inclusion phases which form as 1:1 binary compounds in the systems. The irreversible cyclization of the Leu-Ala host molecule when the molecule is a part of various inclusion compounds or a guest-free solid phase of the dipeptide was studied. The inclusion of water in Leu-Ala was studied by the determination of the sorption isotherm at 298 K and crystal phase analysis of the sorption products. This work presents the first comprehensive study on the clathration ability of a layered peptide matrix as a host material.



leucyl-alanine, inclusion compounds, clathration, sorption