Role of 10- and 14-carbon alkanes in H11 phase of DOPE

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Cleve, Richard Hermann

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University of Guelph


Small, hydrophobic molecules such as n-decane and n-tetradecane are known to be inverse hexagonal (H\sbII) phase promoters. n-tetradecane also causes an increase in the hexagonal phase repeat distance whereas n-decane shows no change in the repeat distance. In this study NMR spectroscopy and NMR relaxation (T\sb1z, T\sbsp2qe, and T\sbsp2qCPMG) were used to study the perdeuterated C\sb?D\sb30 and C\sb?D\sb30 molecules in a DOPE-water system. The tetradecane spectrum and relaxation data showed very little change on reducing the water content from excess water to osmotically stressed, 87.5% weight. The decane showed a slight increase in order and a shortened T\sbsp2qe on osmotic stressing. These data are inconsistent with the existing "space-filling" model. While no model can be constructed on the basis of this new data, the data provide constraints for new models of alkane-phospholipid interaction.



hydrophobic molecules, carbon alkanes, n-decane, n-tetradecane, perdeuterated, DOPE-water system, water content, osmotic stressing, alkane-phospholipids, interaction