The common bean (Phaseolus vulgaris L.) is an important food crop in the world. Anthracnose of common bean, caused by the fungus Colletotricum lindemuthianum, is a major and worldwide destructive disease. A population of 126 F5:6 recombinant inbred lines (RILs) of a cross between the resistant navy bean Bolt and the susceptible H4784A-29844, was phenotyped in the field and growth room trials and genotyped with genome-wide single nucleotide polymorphic markers. The resistance appeared to be controlled by a major QTL on Pv01, likely associated with the anthracnose resistance gene Co-1. In-Silico search in the Phaseolus reference genome resulted in identification of four candidate genes in the QTL region. Sequence comparison of the amplified coding regions of these genes revealed structural differences in resistant and susceptible genotypes.