The influence of inflammation on hemostatic assays
This thesis is an investigation of the potential influence of inflammation on several hemostatic assays. Blood samples were collected from canine patients on admission to the intensive care unit (ICU) and markers of inflammation [neutrophil count and C-reactive protein (CRP)] were correlated to 6 hemostatic parameters [activated clotting time (ACT), prothrombin time (PT), activated partial thromboplastin time (aPTT), antithrombin (AT), endogenous thrombin potential (ETP), and platelet count]. Blood from a subset of these patients was also collected daily until either discharge from the ICU, euthanasia, or death to assess the existence of any trending pattern in CRP, ACT, PT, aPTT, AT and ETP in relation to patient outcome. A strong positive correlation was found between CRP and ACT. In patients that survived, the CRP was found to decrease over time. In non-survivors, ACT and aPTT were both prolonged, while AT activity decreased over ICU hospitalization.