Synthesis of an Unnatural Phospholipid for use in Pulmonary Surfactant Therapy

dc.contributor.advisorSchwan, Adrian
dc.contributor.authorBest, Natasha
dc.date.accessioned2012-05-02T19:59:12Z
dc.date.available2012-05-02T19:59:12Z
dc.date.copyright2012-04
dc.date.created2012-04-30
dc.date.issued2012-05-02
dc.degree.departmentDepartment of Chemistryen_US
dc.degree.grantorUniversity of Guelphen_US
dc.degree.nameMaster of Scienceen_US
dc.degree.programmeChemistryen_US
dc.description.abstractNeonatal respiratory distress syndrome (RDS) is a disease that affects premature infants born prior to 32 weeks gestation. The main cause is a deficiency in pulmonary surfactant due to immature type II pneumocyte cells found in the alveoli. These cells are not capable of producing the required surfactant which normally functions to reduce the surface tension at the air-liquid interface of the lungs, as well as reduce the work of breathing and prevent alveolar collapse. A current treatment method for RDS is exogenous surfactant replacement therapy involving application of an exogenous surfactant preparation directly into the lungs of premature infants. Current surfactant preparations are animal-derived and very costly. Synthetic preparations, on the other hand, are an attractive alternative. The goal of this research is to synthesize a diether phosphonolipid analogue of dipalmitoyl phosphatidylcholine (DPPC), designated DEPN-8. When incorporated into a synthetic exogenous surfactant mixture, DEPN-8 exhibits greater adsorption and surface activity compared to its natural counterpart, DPPC. The synthesis of several components related to the re-tailored synthesis of DEPN-8 will be presented and discussed below.en_US
dc.description.sponsorshipNational Institute of Health
dc.description.sponsorshipNatural Sciences and Engineering Research Council of Canada
dc.identifier.urihttp://hdl.handle.net/10214/3549
dc.language.isoenen_US
dc.publisherUniversity of Guelphen_US
dc.rights.licenseAll items in the Atrium are protected by copyright with all rights reserved unless otherwise indicated.
dc.subjectphospholipiden_US
dc.subjectphosphonolipiden_US
dc.subjectsurface tensionen_US
dc.subjectsurfactanten_US
dc.subjectrespiratory distress syndromeen_US
dc.titleSynthesis of an Unnatural Phospholipid for use in Pulmonary Surfactant Therapyen_US
dc.typeThesisen_US

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