Chemokine and chemokine decoy receptor contributions to fetal success and failure during porcine pregnancy

dc.contributor.advisorHanel, Ann
dc.contributor.advisorTayade, Chandra
dc.contributor.advisorCroy, B. Anne
dc.contributor.authorWessels, Jocelyn Marika of Biomedical Sciencesen_US of Guelphen_US of Scienceen_US
dc.description.abstractTwo waves of spontaneous fetal loss occur during commercial swine pregnancy; one during early and the other during mid-pregnancy. Decreased angiogenesis and increased pro-inflammatory cytokines have been found at arresting fetal attachment sites. However, levels of chemokines, small molecules responsible for chemoattraction, and their regulators, decoy receptors, are not reported. I hypothesized that decoy receptors contribute to fetal demise by altering endometrial cell trafficking via chemokine degradation. Select chemokines and decoy receptors were quantified at the maternal-fetal interface. Transcript number of homeostatic decoy receptor 'CCX CKR' was significantly higher in arresting gd50 tissues, compared with healthy gd50 tissues. Immunohistological localization of CCL4, CCX CKR, and D6 confirmed their expression in endometrium. The differential expression of chemokines and decoy receptors between healthy and arresting attachment sites may contribute to conceptus fate by altering the ratios of recruited cell types at the maternal-fetal interface.en_US
dc.publisherUniversity of Guelphen_US
dc.rights.licenseAll items in the Atrium are protected by copyright with all rights reserved unless otherwise indicated.
dc.subjectchemokine decoy receptoren_US
dc.subjectfetal successen_US
dc.subjectfetal lossen_US
dc.subjectporcine pregnancyen_US
dc.titleChemokine and chemokine decoy receptor contributions to fetal success and failure during porcine pregnancyen_US


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