Effects of BPA and BPS on the Anti-Mullerian Hormone Receptor and Downstream SMAD Proteins in Bovine Granulosa Cells

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dc.contributor.advisorFavetta, Laura
dc.contributor.authorPatel, Rushi
dc.date.accessioned2022-09-07T17:46:12Z
dc.date.available2022-09-07T17:46:12Z
dc.date.copyright2022-09
dc.date.created2022-08-31
dc.degree.departmentDepartment of Biomedical Sciencesen_US
dc.degree.grantorUniversity of Guelphen_US
dc.degree.nameMaster of Scienceen_US
dc.degree.programmeBiomedical Sciencesen_US
dc.description.abstractExposure to endocrine-disrupting chemicals (EDCs), such as Bisphenol A (BPA) and Bisphenol S (BPS) has been shown to have consequences for embryonic development through the dysregulation of several hormonal pathways governing reproduction. Anti-Mullerian hormone (AMH), a positive predictor of fertility, has been shown to be affected by exposure to bisphenols, however, the interaction between bisphenols and mediators of the AMH pathway has not yet been clarified. This study evaluated the effects of BPA and BPS on the AMH signaling pathway in bovine granulosa cells through the analysis of AMH receptor (AMHRII) and SMADs, downstream signaling effectors in the AMH pathway. Our findings show that BPA alters SMAD expression and BPS alters AMHRII expression in normal and AMHRII knocked-down granulosa cells respectively. This study suggests that BPA exerts its effects independently of the AMH receptor while BPS may act directly through the AMH signaling pathway providing further evidence against the safety of both BPA and its analogs.en_US
dc.description.sponsorshipNatural Sciences and Engineering Research Council of Canada
dc.identifier.citationPatel R. H., Truong V. B., Sabry R., McCahill K., Favetta L. A. (2021) 48�?�Bisphenols modulate the anti-M?�llerian hormone system in bovine granulosa cells cultured in vitro. Reproduction, Fertility and Development 34, 259-259. doi:10.1071/RDv34n2Ab48. PMID: 35231302.
dc.identifier.urihttps://hdl.handle.net/10214/27184
dc.language.isoenen_US
dc.publisherUniversity of Guelphen
dc.rights.licenseAll items in the Atrium are protected by copyright with all rights reserved unless otherwise indicated.
dc.subjectBisphenol Aen_US
dc.subjectAnti-Mullerian Hormoneen_US
dc.subjectSMADen_US
dc.subjectEndocrine Disrupting Chemicalsen_US
dc.subjectFolliculogenesisen_US
dc.subjectReproductionen_US
dc.subjectAMH Signalingen_US
dc.subjectAMHRII Knockdownen_US
dc.subjectBovineen_US
dc.subjectGranulosa Cellsen_US
dc.titleEffects of BPA and BPS on the Anti-Mullerian Hormone Receptor and Downstream SMAD Proteins in Bovine Granulosa Cellsen_US
dc.typeThesisen_US
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