Fertility, granulosa cells, and control of the protein Thrombospondin-1

Date
2013-03-04
Authors
McGray, A.J.R.
Gingerich, T.
Petrik, J.J.
LaMarre, J.
Institute for Community Engaged Scholarship
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Abstract

Eggs mature in a complex environment surrounded by granulosa cells that nurture and interact with the egg. TSP-1 is a protein known to influence granulosa cell development. Specific switches turn the gene for TSP-1 on or off, influencing the amount of protein present in the cell and thus influencing fertility.

Description
This summary is a project of the Institute for Community Engaged Scholarship (ICES) at the University of Guelph, with project partners: the Catalyst Centre, SPARK Program at the University of Guelph, and Knowledge Mobilization Unit at York University. This project is part of the Pan-Canadian Research Impact Network. http://csahs.uoguelph.ca/pps/Clear_Research
Keywords
fertility, granulosa cells, TSP-1, IGF-1, genes, proteins, switches
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