The Epigenetic Transmission of Maternal Effects in Mammals: Evaluating and Extending Laboratory Knowledge to Natural Ecosystems

dc.contributor.advisorNewman, Amy
dc.contributor.authorMorey, Kevin
dc.date.accessioned2018-11-28T16:44:18Z
dc.date.available2019-11-02T05:00:35Z
dc.date.copyright2018-11-02
dc.date.created2018-11-02
dc.date.issued2018-11-28
dc.degree.departmentDepartment of Integrative Biologyen_US
dc.degree.grantorUniversity of Guelphen_US
dc.degree.nameMaster of Scienceen_US
dc.degree.programmeIntegrative Biologyen_US
dc.description.abstractEpigenetic maternal effects are being studied in laboratories at an exponentially increasing rate and have routinely been found to have consequences on the physiological and behavioural function of mammalian offspring. Despite this wealth of knowledge, our understanding of how epigenetic maternal effects impact free-living animals within natural ecosystems is comparatively non-existent. Here, I examine laboratory epigenetic maternal effects literature from the last decade with a perspective informed by an eco-evolutionary framework and found that the type and timing of maternal effects influences the extent of offspring DNA methylation in mammals. Additionally, I use an innovative experimental field manipulation to assess the epigenetic maternal effects of stress in free-living North American red squirrels and found inherent sex-specific differences in Nr3c1 and Pomc gene expression of red squirrel offspring despite no effect of maternal stress. Together, these studies highlight the importance of integrating evolutionary, ecophysiological, and molecular theory when studying epigenetic maternal effects.en_US
dc.description.sponsorshipNatural Sciences and Engineering Research Council of Canada
dc.description.sponsorshipUniversity of Guelph
dc.description.sponsorshipMinistry of Training, Colleges, and Universities
dc.description.sponsorshipAmerican Society of Mammalogists (GIAR)
dc.identifier.urihttp://hdl.handle.net/10214/14429
dc.language.isoenen_US
dc.publisherUniversity of Guelphen_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectEpigeneticsen_US
dc.subjectMaternal Effectsen_US
dc.subjectStress Physiologyen_US
dc.subjectDNA methylationen_US
dc.subjectmRNA expressionen_US
dc.titleThe Epigenetic Transmission of Maternal Effects in Mammals: Evaluating and Extending Laboratory Knowledge to Natural Ecosystemsen_US
dc.typeThesisen_US

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