The Examination of Gas-Phase Ion-Neutral Reactions in a nESI-FAIMS-QTOF and ESI-Quadrupole Ion Trap through the Analysis of Thiotetronic Acids and N-Nitrosodialkylamines

dc.contributor.advisorGabryelski, Wojciech
dc.contributor.authorRobinson, Jennifer
dc.date.accessioned2018-04-30T15:27:12Z
dc.date.available2018-04-30T15:27:12Z
dc.date.copyright2018-04
dc.date.created2018-04-18
dc.date.issued2018-04-30
dc.degree.departmentDepartment of Chemistryen_US
dc.degree.grantorUniversity of Guelphen_US
dc.degree.nameMaster of Scienceen_US
dc.degree.programmeChemistryen_US
dc.description.abstractThe reactions of gas-phase ions with neutral molecules in mass spectrometry were investigated. These reactions are rare, due to high vacuum conditions and the high purity of collision gases. The ions of interest originated from the dissociation of thiotetronic acids (TA) and N-Nitrosamines (NDAA). Using soft MS, the structure and properties of TAs were determined. They formed ketene ions which then reacted with water in the collision cell. NDAAs were analysed using sequential tandem MS. The CID products parallel the metabolites produced in biological systems. The size of the aliphatic group determined the alkylating potential of the nitrosamine. The comparison of spectral intensities between isotopically unlabelled NDPA and isotopically labelled NDPA-d14 helped to determine the protonation of diazoic acids is the rate limiting step in the dissociation of diazoic. The addition of water in these dissociation pathways provides better understanding of ion-molecule reactions in MS.en_US
dc.identifier.urihttp://hdl.handle.net/10214/12939
dc.language.isoenen_US
dc.publisherUniversity of Guelphen_US
dc.rights.licenseAll items in the Atrium are protected by copyright with all rights reserved unless otherwise indicated.
dc.subjectThiotetronic Acidsen_US
dc.subjectFAIMSen_US
dc.subjectMass Spectrometryen_US
dc.subjectN-nitrosaminesen_US
dc.titleThe Examination of Gas-Phase Ion-Neutral Reactions in a nESI-FAIMS-QTOF and ESI-Quadrupole Ion Trap through the Analysis of Thiotetronic Acids and N-Nitrosodialkylaminesen_US
dc.typeThesisen_US

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