Exploring Methodological Issues in Modelling Antimicrobial Resistance using Generic Escherichia coli Isolates from Chicken Abattoir and Retail Meat Surveillance in Canada

dc.contributor.advisorMcEwen, Scott
dc.contributor.authorMacKinnon, Melissa
dc.date.accessioned2017-08-21T18:37:31Z
dc.date.available2017-08-21T18:37:31Z
dc.date.copyright2017-07
dc.date.created2017-07-27
dc.date.issued2017-08-21
dc.degree.departmentDepartment of Population Medicineen_US
dc.degree.grantorUniversity of Guelphen_US
dc.degree.nameMaster of Scienceen_US
dc.degree.programmePopulation Medicineen_US
dc.description.abstractComparisons were made of the performance of different regression models for analysis of annual variation in susceptibility of generic Escherichia coli isolates to ceftiofur, ampicillin and nalidixic acid from retail chicken surveillance. Secondly, impacts of using different multidrug resistance (MDR) classification metrics for the analysis of annual variation in MDR were evaluated using generic E.coli isolates from chicken abattoir surveillance. Antimicrobial susceptibility data were obtained from the Canadian Integrated Program for Antimicrobial Resistance Surveillance. Model assumptions were met using logistic and multinomial regression. Linear, tobit, ordinal and complementary log-log regression did not meet model assumptions and/or did not perform well. Significant annual variation in susceptibility to all three antimicrobials was identified with multinomial regression, whereas logistic regression only identified significant annual variation in susceptibility to ceftiofur. Both the prevalence of MDR and interpretation of the association between MDR, and year and region differed depending on the MDR classification metric used.en_US
dc.description.sponsorshipCanadian Institute of Health Research
dc.description.sponsorshipCanadian Graduate Scholarship - Master's Award
dc.description.sponsorshipOntario Veterinary College
dc.identifier.urihttp://hdl.handle.net/10214/11442
dc.language.isoenen_US
dc.publisherUniversity of Guelphen_US
dc.rightsAttribution-NoDerivs 2.5 Canada*
dc.rights.urihttp://creativecommons.org/licenses/by-nd/2.5/ca/*
dc.subjectAntimicrobial resistanceen_US
dc.subjectMultidrug resistanceen_US
dc.subjectSurveillanceen_US
dc.subjectEscherichia colien_US
dc.subjectE. colien_US
dc.subjectChickenen_US
dc.subjectEpidemiologyen_US
dc.subjectBiostatisticsen_US
dc.subjectStatistical Modellingen_US
dc.titleExploring Methodological Issues in Modelling Antimicrobial Resistance using Generic Escherichia coli Isolates from Chicken Abattoir and Retail Meat Surveillance in Canadaen_US
dc.typeThesisen_US

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