Comparison of recurrent and sporadic Clostridium difficile infection and microbiological investigation of response of recurrent Clostridium difficile infection to fecal microbiota transplantation

dc.contributor.advisorBersenas, Alexa
dc.contributor.advisorWeese, Scott
dc.contributor.advisorKim, Peter
dc.contributor.authorRichardson, Connor
dc.date.accessioned2014-05-05T18:20:14Z
dc.date.available2014-05-05T18:20:14Z
dc.date.copyright2014-04
dc.date.created2014-04-23
dc.date.issued2014-05-05
dc.degree.departmentDepartment of Clinical Studiesen_US
dc.degree.grantorUniversity of Guelphen_US
dc.degree.nameMaster of Scienceen_US
dc.degree.programmeClinical Studiesen_US
dc.description.abstractThis thesis investigates the strain distribution and characteristics of Clostridium difficile recovered from patients with sporadic and recurrent diarrhea. Samples were collected from patients with both recurrent and sporadic disease and ribotyping was conducted to determine the strain distribution, in particular examining the prevalence of NAP1/027. Antimicrobial susceptibility to vancomycin and metronidazole was determined using E-tests. It was found that both gender (female) and NAP1/027 were positively associated with recurrent disease. For patients undergoing human biotherapy for treatment of recurrent disease, pre and post-treatment samples were ribotyped. It was found that NAP1/027 was present in high proportions in individuals after clinical cure, however, no association was determined between the presence of C. difficile and response to fecal microbiota transplantation (FMT)treatment.en_US
dc.description.sponsorshipCanadian Institutes of Health Research (CIHR)
dc.description.sponsorshipNatural Sciences and Engineering Research Council of Canada
dc.description.sponsorshipCollaborative Health Research Projects (project 413548-2012)
dc.identifier.urihttp://hdl.handle.net/10214/8044
dc.language.isoenen_US
dc.publisherUniversity of Guelphen_US
dc.rights.licenseAll items in the Atrium are protected by copyright with all rights reserved unless otherwise indicated.
dc.subjectClostridium difficileen_US
dc.subjectC. difficileen_US
dc.subjectCDIen_US
dc.subjectSporadicen_US
dc.subjectRecurrenten_US
dc.subjectFecal Microbiota Transplanten_US
dc.subjectribotypingen_US
dc.subjectNAP1/027en_US
dc.titleComparison of recurrent and sporadic Clostridium difficile infection and microbiological investigation of response of recurrent Clostridium difficile infection to fecal microbiota transplantationen_US
dc.typeThesisen_US

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