The effect of endogenous and exogenous N-3 polyunsaturated fatty acids on mammary gland development and fatty acid composition in FVB mice

dc.contributor.advisorMa, David W.L.
dc.contributor.authorAnderson, Breanne M.
dc.date.accessioned2020-08-24T15:43:43Z
dc.date.available2020-08-24T15:43:43Z
dc.date.copyright2010
dc.degree.departmentDepartment of Human Biology adn Nutritional Sciencesen_US
dc.degree.grantorUniversity of Guelphen_US
dc.degree.nameMaster of Scienceen_US
dc.description.abstractThis thesis is an investigation of the effects of n-3 polyunsaturated fatty acids (PUFA) derived from diet or endogenously via the fat-1 gene from conception through puberty on mammary gland development and fatty acid composition in both wild-type (WT) and transgenic (TG) mice. N-3 PUFA from both diet and genetics were enriched in the mammary glands of mice as early as 3 weeks of age and elevated levels persisted through 12 weeks, however dietary exposure resulted in a relatively greater incorporation of n-3 PUFA compared to genetics. Significant effects of n-3 PUFA on mammary gland development were noted at 3 and 4 weeks of age and a dose-dependant delay in pubertal onset was associated with elevated n-3 PUFA status. Overall, findings suggest that prepuberty might be a time when mammary gland development is particularly sensitive to dietary modifications which, may play a role in modifying future breast cancer risk.en_US
dc.identifier.urihttps://hdl.handle.net/10214/19688
dc.language.isoen
dc.publisherUniversity of Guelphen_US
dc.rights.licenseAll items in the Atrium are protected by copyright with all rights reserved unless otherwise indicated.
dc.subjectN-3 polyunsaturated datty acidsen_US
dc.subjectDieten_US
dc.subjectMammary glanden_US
dc.subjectDevelopmenten_US
dc.subjectBreast canceren_US
dc.titleThe effect of endogenous and exogenous N-3 polyunsaturated fatty acids on mammary gland development and fatty acid composition in FVB miceen_US
dc.typeThesisen_US

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