Cannabinoids found naturally in the brain may suppress vomiting and nausea
Date
2013-04-19
Authors
Sticht, M.A.
Long, J.Z.
Rock, E.M.
Limebeer, C.L.
Mechoulam, R.
Crvatt, B.F.
Parker, L.A.
Institute for Community Engaged Scholarship
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Abstract
The naturally occurring cannabinoid 2AG suppressed vomiting in shrews by attaching to the CB1 receptor. 2AG, along with its metabolite, AA, also suppressed nausea-induced conditioned gaping in rats, but this effect was largely independent of CB1 (or CB2) receptors.
Description
This summary is a project of the Institute for Community Engaged Scholarship (ICES) at the University of Guelph, with project partners: the Catalyst Centre, SPARK Program at the University of Guelph, and Knowledge Mobilization Unit at York University. This project is part of the Pan-Canadian Research Impact Network. http://csahs.uoguelph.ca/pps/Clear_Research
Keywords
Nausea, vomiting, rats, shrews, endocannabinoid system, cannabinoids