The neurobiology of environmentally induced stereotypic behaviours in barren versus enriched housed laboratory mice (Mus musculus)

dc.contributor.advisorMason, Georgia
dc.contributor.authorKitchenham, Lindsey of Animal Biosciencesen_US Centre for the Study of Animal Welfareen_US of Guelphen_US of Scienceen_US and Poultry Scienceen_US
dc.description.abstractThe neurobiology of environmentally induced stereotypic behaviours (e.g. pacing in zoo carnivores, crib-biting in horses) is hypothesized to involve the disruption of coordinated function within the basal ganglia (’Basal Ganglia [BG] Pathways Hypotheses’) and/or between the basal ganglia and the cortex (‘Cortico-Striatal-Thalamo-Cortical [CSTC] Circuits Hypotheses‘). However, these hypotheses have not yet been fully supported by the current research. Currently tests of these hypotheses in mice (Mus musculus) are incomplete: missing regions of interest, housing, or individual difference effects. My research used cytochrome oxidase histochemistry to examine neuronal activity in each of the basal ganglia nuclei for enriched versus barren housed mice and assessed whether basal ganglia activity correlated with SBs. None of the BG Pathways hypotheses were supported. Thus, the neurobiological mechanism for mouse SBs remains unknown. Further research is important for understanding the impact of captivity on animals’ functioning, and whether SBs are a sign of pathology.en_US
dc.description.sponsorshipQueen Elizabeth II Graduate Scholarship in Science and Engineering
dc.description.sponsorshipOntario Graduate Scholarship
dc.publisherUniversity of Guelphen_US
dc.rights.licenseAll items in the Atrium are protected by copyright with all rights reserved unless otherwise indicated.
dc.subjectBasal Gangliaen_US
dc.subjectCortico-Striatal-Thalamo-Cortical Circuitsen_US
dc.subjectStereotypic Behaviouren_US
dc.subjectEnvironmental Enrichmenten_US
dc.subjectMus Musculusen_US
dc.subjectCytochrome Oxidaseen_US
dc.subjectLaboratory Miceen_US
dc.titleThe neurobiology of environmentally induced stereotypic behaviours in barren versus enriched housed laboratory mice (Mus musculus)en_US


Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
3.23 MB
Adobe Portable Document Format
Thesis - Abstract corrected