A genetic perspective on enzootic bovine leukosis resistance in Canadian Holstein cattle

dc.contributor.advisorBaes, Christine
dc.contributor.authorBongers, Renee
dc.date.accessioned2023-01-12T20:34:37Z
dc.date.available2023-01-12T20:34:37Z
dc.date.copyright2023-01
dc.date.created2023-01-09
dc.degree.departmentDepartment of Animal Biosciencesen_US
dc.degree.grantorUniversity of Guelphen
dc.degree.nameMaster of Scienceen_US
dc.degree.programmeAnimal Biosciencesen_US
dc.description.abstractBovine leukemia virus (BLV) is the causative agent of enzootic bovine leukosis (leukosis). Infection with BLV can lead to persistent lymphocytosis and tumours and is associated with decreased production, and immune and fertility challenges. Reducing the prevalence of leukosis through management and culling has not yet been successful; therefore, this thesis aimed to examine leukosis resistance from a genetic perspective. Approximately 77% of herds tested in this study were positive for leukosis; within those herds, an average of 39% of cows tested were positive for leukosis. A heritability of 0.10 (SE=0.001) and 0.07 (SE=0.0006) was estimated for leukosis resistance using a linear animal model and single-step GBLUP methodology, respectively. Candidate genes associated with leukosis resistance were identified on chromosome 23 using a genome-wide association study. Overall, selection for leukosis resistance is possible and this thesis provides the foundations for the inclusion of leukosis resistance in Canadian national selection indices.en_US
dc.identifier.urihttps://hdl.handle.net/10214/27438
dc.language.isoenen_US
dc.publisherUniversity of Guelphen
dc.rights.licenseAll items in the Atrium are protected by copyright with all rights reserved unless otherwise indicated.
dc.subjectbovine leukemia virusen_US
dc.subjectenzootic bovine leukosisen_US
dc.subjectgenetic selectionen_US
dc.subjecthealthen_US
dc.subjectheritabilityen_US
dc.subjectneoplastic diseaseen_US
dc.subjectdairy cattleen_US
dc.subjectdisease traitsen_US
dc.subjectGWASen_US
dc.subjectgenomic selectionen_US
dc.titleA genetic perspective on enzootic bovine leukosis resistance in Canadian Holstein cattleen_US
dc.typeThesisen

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